Vaccination has greatly diminished death, illness and suffering in the world. But no other medical technology has been so dogged with controversy. The book chronicles the development of the key lifesaving vaccines since the 18th century. It tells the stories of great scientists and their discoveries, of the protests and pain along the stumbling path of progress. This is the first book to tell the whole story of vaccination for a general audience. In light of controversies about flu vaccine and autism, it will be of particular interest to parents, pediatricians, public health workers and anyone fascinated by medical history. Read More>>

Also Available: Table of Contents and Index

Arthur Allen is a Washington DC-based journalist who has written on vaccine issues in The New York Times Magazine, the Washington Post Magazine, The New Republic, Atlantic Monthly, Salon and Slate.

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Autism, the 'Environment' and the IOM

The Institute of Medicine held a workshop this past week to examine research into the "environmental" causes of autism. It was an opportunity for discussion among scientists pursuing possible links, and a chance for some of the autism "advocacy" community to press their research priorities. No less a bigwig than Alan Leshner, president of the AAAS and editor of Science, presided over the meeting, also attended by the directors of two of the National Institutes of Health.

The opinions of the parents of autistics, especially angry parents, occupy pride of place in our Oprah-fied public culture. Ignore them at your own peril. This is not an entirely bad thing. But there's a weird disparity between what's expected of the scientists and advocates in a setting like this.

The increasing public scrutiny of scientific conflicts of interest is no doubt a good thing. In the scientific culture, scientists are expected to acknowledge biases. In the "comments" section of journal articles, for example, scientists are in the habit of playing the devil's advocate by explaining how their results may have been skewed by the structure of their data or data collection; this is a recognition of the fact that many a scientific paper's results fails to be reproducible. Scientists are also obliged by most journals to describe any financial or relational bias that may impact the work, such as funding from a pharmaceutical company.

Public advocates have no such demands on them, and that was what was disturbing about the IOM workshop. Many of the scientists in this field and at the workshop table were drawn into it by the fact that they have autistic-spectrum children; that's a bias, of sorts, but it's also a strong motivation to find the truth. But there were others at the meeting who were there simply to badger the government and scientists about their own pet theory, that autism is caused by toxins, particularly the mercury-based preservative thimerosal. The demeanor of people who buy this theory ranges from ranting and profane to slick and professional. As someone who entered the debate about this theory, in 2002, with an open mind, but has come to the strong conclusion that there is no basis for blaming vaccines for an "epidemic" that may not even exist, I find some of the individuals in these groups, especially in SafeMinds, to be disingenuous. They are playing at scientific seriousness while refusing to acknowledge the data.

Study after study has shown no link between thimerosal and autism. The rates of autism continue to grow in cohorts of children who received no thimerosal-containing vaccines.

None of this makes an impact on some SafeMinds activists, who insist there is an epidemic of autism caused by mercury. The fact that rates of autism haven't decreased despite the removal of thimerosal from vaccines doesn't faze them. It's the poisoning of the wombs of pregnant women with thimerosal-containing flu shots, they insist (although only something like 10 percent of pregnant women get this shot), and flu vaccination of toddlers (according to a 2004 NHIS immunization survey, only 18 % of children 6--23 months got one or more flu shots).

If thimerosal was truly the cause of a huge upswing in autism beginning in the 1990s, we'd have seen the rates plummet since the substance was removed from the Hep B, HiB and DTP shots starting in 1999 (by early 2002, according to an informal CDC spot check of 150,000 doses of these vaccines at 447 provider sites in 25 states, 1.9 percent contained thimerosal). To make this crystal clear for those with stuff in their ears:

1950 --- ~ 1992:   80-90 percent of U.S. children get 3 DTP shots with thimerosal by age 6 months

~1993 -- 1999:     80-90 percent of U.S. children get 9 thimerosal-containing shots by 6 months of age

~2000 -- present:    20   percent of U.S. children get 1-2 flu shots (many of which contain thimerosal) between the ages of 6 and 23 months.

No one can be sure there hasn't been some increase in autism in the last couple of decades, but we can be sure that it isn't the huge, 10-fold increase that people like SafeMinds' Mark Blaxill are touting. And we can also be sure of another thing: thimerosal in vaccines isn't responsible for any increase.

Many of the people in the "mercury" camp (including SafeMinds' Lyn Redwood, and NAA's Laura Bono) are or were involved in lawsuits charging that their children were made autistic by mercury. And as Blaxill himself has pointed out (for example in a 2005 meeting at the CDC), you don't have to have a financial conflict of interest to cling stubbornly to a flawed position. It's enough to cling to your professional pride, or to belong to a community of belief that will heckle or ostracize you if you step out of line (Blaxill, at the time, was talking about what he perceived as the pediatrics community's unwillingness to face the fact that it had been poisoning kids for  years). After you've spent years shouting at the government, participating in flawed Congressional hearings, writing junky "investigational" books and reports, encouraging lawsuits that cost the public and the drug companies hundreds of millions of dollars, and spreading unfounded slander against government scientists on the Web, it's pretty darn hard to step back and say, "Whoops, I was wrong." I just wish I could find someone--anyone--willing to do that.

We should demand a lot of government scientists and public health officials. But a sense of responsibility isn't just for government workers.

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Comments

Bartholomew Cubbins

So this was news to me: the people who are badgering the government to focus on their beliefs are the same ones bringing lawsuits against the government and pharmaceuticals?

isles

Oh heck yeah.

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